Biofilm and Cancer: Interactions and Future Directions for Cancer Therapy

There is a growing body of evidence supporting the significant role bacterial biofilms in pathogenesis various human diseases, including cancer. Biofilms are polymicrobial communities enclosed within an extracellular matrix composed polysaccharides, proteins, DNA, and lipids. This complex provides protection against antibiotics host immune responses, enabling microorganisms to establish persistent infections. Moreover, induce anti-inflammatory responses metabolic changes host, further facilitating their survival. Many these comparable those observed cancer cells. review will cover recent research on carcinogenesis, especially colorectal (CRC) gastric cancers, emphasizing shared physical chemical characteristics also discuss interactions between bacteria tumor microenvironment, which can facilitate oncogene expression progression. information provide insight into developing new therapies identify treat biofilm-associated such as utilizing delivery vectors, using upregulate function, or more selectively targeting for traits.